1.Antidepressants are very hit-and-miss
Unfortunately, for around half of depressed patients, the first antidepressants prescribed do not work.
On top of that, around one-third of patients do not respond to any types of drugs (although psychological therapies may be useful).
At the moment, the only way to know is to try them and see what happens.
This means that many depressed people have to wait around three months to see if the drugs will work.
2. Science of antidepressants based on backward facts
The scientific basis behind commonly used antidepressants is completely backwards, according to a new review of the research.
For almost 50 years it has been believed by scientists and the public alike that depression is related to low levels of serotonin in the brain.
In fact, the new review finds, the very best evidence available suggests people who are depressed actually have higher levels of serotonin in their brains, not lower.
This means that commonly used antidepressants are actually making the situation worse, not better.
3. Some scientists say they don’t work
New generation ‘SSRI’ antidepressants like Prozac or Seroxat mostly fall, “below the recommended criteria for clinical significance”, according to some scientists.
In other words, the most modern drugs prescribed for depression generally don’t work.
Their review of the evidence found the drugs had different effects on people with different levels of depression:
- Mild depression: not tested as mild depression is usually treated with a ‘talk therapy’ rather than antidepressants.
- Moderate depression: antidepressants made “virtually no difference”.
- Severe depression: antidepressants had a “small and clinicallyinsignificant” effect.
- Most severe depression: antidepressants had a significant clinical benefit – but see the full article.
For the full story: SSRI Antidepressants ‘Clinically Insignificant’ For Most People
4. Hidden side-effects
A recent survey of people taking antidepressants has found higher than expected levels of emotional numbness, sexual problems and even suicidal thoughts associated with the medication
The study, published in the journal Psychiatry Research, found that as many as half the people they surveyed had psychological problems due to their medication.
Of the 20 adverse effects that people were questioned about:
- 62% said they had ‘sexual difficulties’,
- 52% said they ‘didn’t feel like themselves’,
- 42% noticed a ‘reduction in positive feelings’,
- 39% found themselves ‘caring less about others’,
- and 55% reported ‘withdrawal effects’.
Set against these findings, though, 82% said that the drugs had been useful in tackling their depression.
5. Most linked to weight gain
Bupropion, which is marketed as Wellbutrin, is the only antidepressant linked to weight loss, new research finds.
In contrast, those taking fluoxetine (known mainly as Prozac) gained an average of 4.6 pounds in the same time.
So, those taking Wellbutrin weighed an average of 7 pounds less than those who took Prozac over the two years.
6. Memory loss
The older type of antidepressants — known as tricyclics — have been linked to memory loss.
Some of the drug names include:
- desipramine (Norpramin),
- imipramine (Tofranil),
- clomipramine (Anafranil),
- and doxepin (Sinequan).
Around half of people taking them report problems concentrating and one-third say they have memory loss.
7. Natural supplements can boost effectiveness
Four natural supplements have been found by new research to increase the effectiveness of antidepressants.
The supplements are:
- Omega 3 fish oils,
- S-adenosylmethionine (SAMe),
- methylfolate (bioactive form of folate),
- and vitamin D.
The conclusions come from a new review of 40 clinical trials carried out worldwide.
Each tested the use of common antidepressants in tandem with dietary supplements.
8. Antidepressants linked to autism
Mothers who use antidepressants during pregnancy could double their children’s risk of develop autism.
The conclusions come from a new study covering 145,456 pregnancies.
Since around 7% of pregnant women take antidepressants, the study could have very important implications.
9. Self-harm and suicide
A common antidepressant thought safe for adolescents is actually ineffective, new research finds.
Worse, it has been linked to serious side-effects.
The drug is called paroxetine, which is marketed as Paxil, Seroxat and Aropax.
10. Antidepressants and social anxiety
Social anxiety disorder is most commonly treated with antidepressants, but these are not the most effective treatment.
A new study finds that cognitive behavioural therapy (CBT) is more effective and the benefits continue after the initial treatment has finished.
The researchers found that it was the psychological therapies that were the most effective.
As a result these should be the first choice treatment.
About the author
Psychologist, Jeremy Dean, PhD is the founder and author of PsyBlog. He holds a doctorate in psychology from University College London and two other advanced degrees in psychology.
He has been writing about scientific research on PsyBlog since 2004. He is also the author of the book “Making Habits, Breaking Habits” (Da Capo, 2013) and several ebooks:
- Accept Yourself: How to feel a profound sense of warmth and self-compassion
- The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic
- Spark: 17 Steps That Will Boost Your Motivation For Anything
- Activate: How To Find Joy Again By Changing What You Do
Antidepressants were also effective, but were associated with side-effects, and they don’t work for some people.