4 Natural Supplements Found To Boost Antidepressant Effectiveness

Antidepressants are more effective in concert with four common dietary supplements — evidence from 40 clinical trials.

ketamine for depression

Antidepressants are more effective in concert with four common dietary supplements — evidence from 40 clinical trials.

Four natural supplements have been found by new research to increase the effectiveness of antidepressants.

The supplements are:

  1. Omega 3 fish oils,
  2. S-adenosylmethionine (SAMe),
  3. methylfolate (bioactive form of folate),
  4. and vitamin D.

The conclusions come from a new review of 40 clinical trials carried out worldwide.

Each tested the use of common antidepressants in tandem with dietary supplements.

Dr Jerome Sarris, the study’s first author, said:

“The strongest finding from our review was that Omega 3 fish oil – in combination with antidepressants – had a statistically significant effect over a placebo.

Many studies have shown Omega 3s are very good for general brain health and improving mood, but this is the first analysis of studies that looks at using them in combination with antidepressant medication.

The difference for patients taking both antidepressants and Omega 3, compared to a placebo, was highly significant.

This is an exciting finding because here we have a safe, evidence-based approach that could be considered a mainstream treatment.”

Other supplements showed more mixed results, including Vitamin C, zinc, and tryptophan (an amino acid).

There was little evidence for the beneficial effect of folic acid.

Dr Sarris said:

“A large proportion of people who have depression do not reach remission after one or two courses of antidepressant medication.

Millions of people in Australia and hundreds of millions worldwide currently take antidepressants.

There’s real potential here to improve the mental health of people who have an inadequate response to them.

Medical practitioners are aware of the benefits of omega 3 fatty acids, but are probably unaware that one can combine them with antidepressant medication for a potentially better outcome.”

There are no concerns about mixing nutritional supplements with antidepressants, but it is better to consult a professional, Dr Sarris said:

“We’re not telling people to rush out and buy buckets of supplements.

Always speak to your medical professional before changing or initiating a treatment.”

The study was published in the American Journal of Psychiatry (Sarris et al., 2016).


Author: Dr Jeremy Dean

Psychologist, Jeremy Dean, PhD is the founder and author of PsyBlog. He holds a doctorate in psychology from University College London and two other advanced degrees in psychology. He has been writing about scientific research on PsyBlog since 2004.

Get free email updates

Join the free PsyBlog mailing list. No spam, ever.