Category: Nutrition

Vitamin B12 deficiency is relatively common, especially in the elderly.

Problems with thinking and memory can be signs of vitamin B12 deficiency, studies find.

Low levels of vitamin B12, along with other vital nutrients, are linked to brain shrinkage.

Deficiencies in these critical micronutrients may also be important in the development of neurodegenerative diseases like Alzheimer’s.

New research has looked at nutrients in the ‘Mediterranean diet’, which is linked to better brain aging.

It found that people had better cognitive functioning when they had higher levels of important nutrients, including vitamin B12, omega-3 and omega-6 fatty acids, folate and others.

The study included 116 seniors who were given tests of their IQ, memory and thinking skills.

Scans also assessed the efficiency of their brains.

Professor Aron Barbey, study co-author, said:

“Efficiency has to do with how information is communicated within the network.

We looked at ‘local efficiency’ – how well information is shared within a spatially confined set of brain regions – and also ‘global efficiency,’ which reflects how many steps are required to transfer information from any one region to any other region in the network.

If your network is more efficiently configured, then it should be easier, on average, to access relevant information and the task should take you less time.”

The results showed that people performed better in the tests if their blood was higher in levels of these nutrients:

• omega-3 and omega-6 fatty acids,
• carotenoids,
• lycopene,
• riboflavin,
• folate,
• vitamin B12
• and vitamin D.

Professor Barbey explained the results:

“Our study suggests that diet and nutrition moderate the association between network efficiency and cognitive performance.

This means that the strength of the association between functional brain network efficiency and cognitive performance is associated with the level of the nutrients.”

Other potential signs of vitamin B12 deficiency include feeling tired, experiencing muscle weakness and being constipated.

Good sources of vitamin B12 include fish, poultry, eggs and low-fat milk.

Fortified breakfast cereals also contain vitamin B12.

The study was published in the journal Neuroimage (Zwilling et al., 2019).

Supplements or foods such as dairy, liver, salmon and eggs can rectify a vitamin B12 deficiency.

A tingling or numbness in the hands, legs or feet can be a sign of vitamin B12 deficiency.

The sensation frequently starts in the feet and moves to the hands.

The feelings may also be linked to problems with walking or even difficulty balancing.

Known to doctors as neuropathy, the problem can affect people of all ages, although it is particularly common in those over 50.

Around one-in-twelve people over 50 experiences the condition.

Other causes of neuropathy include autoimmune processes and genetics — however, the most common cause is diabetes.

Other common signs of vitamin B12 deficiency include jaundice, feeling dizzy and lethargy.

The body uses vitamin B12 to make red blood cells and to keep the nervous system healthy.

The good news is that vitamin B12 is easy to correct either with supplementation or a change in diet.

Foods high in vitamin B12 include dairy foods, beef, salmon, eggs and low-fat milk.

Dr John D. England, a neurologist at Louisiana State University Health Sciences Center in New Orleans, said:

“People with suspected nerve problems should talk to their doctors about screening tests, especially blood glucose, vitamin B12 level and serum protein levels, since these tests can often point to common causes of neuropathy.”

People who may have difficulty getting enough vitamin B12 include vegetarians, older people and those with some digestive disorders, such as Crohn’s disease.

Dr England said:

“There are many people with a neuropathy who have been walking around for years without having been diagnosed and treated.

Both neurologists and people with neuropathy need to know that the appropriate choice of tests is critical to accurate diagnosis.”

The guidelines were published in the American Academy of Neurology.

Those who lack this vitamin are 70 percent more likely to have muscle weakness and physical disability.

Vitamin D deficiency is a risk factor for muscle wasting (atrophy) and loss of muscle strength (dynapenia).

People with low vitamin D levels are more likely to see declines in muscle mass, strength, and function besides loss of bone density, a study reveals.

The research also shows that vitamin D supplementation could reduce the risk of dynapenia in seniors with low serum 25(OH)D levels by 78 percent.

Muscle atrophy and dynapenia can lead to physical disability in later life, indeed individuals with such conditions have a higher incidence of falling, hospitalisation, and premature death.

Professor Tiago da Silva Alexandre, the study’s co-author, said:

“Vitamin D is known to participate in various functions of the organism.

Actually, it’s a hormone and its many roles include helping to repair muscles and releasing calcium for muscle contraction kinetics.

It was therefore expected to cause muscle alterations of some kind.

That’s exactly what our study proved.”

Muscle tissue and bone are connected biochemically and physically so endocrine disorders such as low blood levels of 25-hydroxy vitamin D (25(OH)D) could result in bone loss and decreases in the size, strength and function of muscles.

Muscle weakness increased by 70 percent

In this study, more than 3000 adults with no history of dynapenia were followed over four years.

Serum 25(OH)D levels reflect the amount of vitamin D stored in the body, the concentration above 50 nmol/L is classified as sufficient, between 30 to 50 nmol/L as insufficient, and below 30 nmol/L as deficient.

The study found that participants with vitamin D deficiency were 70 percent more likely to dynapenia than those with sufficient levels.

Mr Maicon Luís Bicigo Delinocente, the study’s first author, said:

“This is itself an important finding as it shows that vitamin D deficiency heightens the risk of muscle weakness by 70%.

However, because we knew there are many worldwide cases of people with osteoporosis who take vitamin supplements, we needed to try to measure the effectiveness of vitamin D supplementation.”

To obtain the correct data, those on vitamin D supplements and those with osteoporosis were excluded from the study.

Mr Delinocente added:

“we found that the risk of developing muscle weakness by the end of the four-year period was 78% higher for subjects with vitamin D deficiency at the start of the study than for subjects with normal vitamin D levels, and 77% higher for those with vitamin D insufficiency [30-50 nmol/L].”

Vitamin D is essential for the absorption of calcium and phosphorus, maintaining cognitive function, and supporting the immune system.

The main way of getting vitamin D is sunlight, but a large area of  the skin requires exposure to the sun for at least 15 to 20 minutes.

Professor Alexandre said:

“The study analyzed data for people who live in the UK.

There are many more days of sunlight per year in Brazil, and yet we’re known to have a high incidence of vitamin D deficiency and insufficiency, especially among older people.

Indeed, this is the case worldwide.

It’s necessary to explain to people that they risk losing muscle strength if they don’t get enough vitamin D.

They need to expose themselves to the sun, eat food rich in vitamin D or take a supplement, and do resistance training exercises to maintain muscle strength.”

The study was published in the journal Calcified Tissue International (Delinocente et al., 2022).

The symptom is not normally painful, but can be irritating.

Twitching around the eyes can be a sign of vitamin B12 deficiency.

The twitch usually occurs in one eye or the other, or just below them.

The symptom is not normally painful, but can be irritating.

The body uses vitamin B12 to make red blood cells and to keep the nervous system healthy.

B12 deficiency has also been linked to facial pain.

The pain can also be felt across the forehead, occasionally coming down to the edge of the nose.

Other, more common signs of vitamin B12 deficiency include feeling tired, experiencing muscle weakness and being constipated.

Vitamin B12 deficiency can also lead to neuropathy.

This can cause a tingling or numbness in the hands, legs or feet.

The sensation frequently starts in the feet and moves to the hands.

The feelings may also be linked to problems with walking or even difficulty balancing.

People who may have difficulty getting enough vitamin B12 include vegetarians, older people and those with some digestive disorders, such as Crohn’s disease.

Vitamin B12 deficiency is easy to rectify with supplements or by dietary changes.

Vitamin B12 levels can be boosted through supplementation or by eating foods such as dairy, liver, salmon and eggs.

Fortified breakfast cereals also contain vitamin B12.

Dr John D. England, a neurologist at Louisiana State University Health Sciences Center in New Orleans, said:

“People with suspected nerve problems should talk to their doctors about screening tests, especially blood glucose, vitamin B12 level and serum protein levels, since these tests can often point to common causes of neuropathy.”

Dr England continued:

“There are many people with a neuropathy who have been walking around for years without having been diagnosed and treated.

Both neurologists and people with neuropathy need to know that the appropriate choice of tests is critical to accurate diagnosis.”

The guidelines were published in the American Academy of Neurology.

Around half the world’s population is deficient in vitamin D.

Tiredness and weak muscles can be a sign of vitamin D deficiency, research finds.

As a result, people with low levels of vitamin D are at double the risk of mobility issues with age, scientists have found.

Other signs of vitamin D deficiency include poor sleep, symptoms of depression and headaches.

The vitamin is thought to play a role in regulating serotonin, a neurotransmitter important for mood.

Around half the world’s population is deficient in vitamin D.

The conclusions about mobility issues come from a study including 2,099 people aged 70-79 whose vitamin D levels were measured.

Dr Denise Houston, the study’s first author, explained the results:

“We observed about a 30 percent increased risk of mobility limitations for those older adults who had low levels of vitamin D, and almost a two-fold higher risk of mobility disability.”

Vitamin D is vital for muscle function and low levels have been linked to diseases including high blood pressure, diabetes and cardiovascular disease.

Dr Houston said:

“Higher amounts of vitamin D may be needed for the preservation of muscle strength and physical function as well as other health conditions.

However, clinical trials are needed to determine whether increasing vitamin D levels through diet or supplements has an effect on physical function.”

Vitamin D is critical to the functioning of the whole body.

From October to March many people in northern climes do not get enough vitamin D.

Vitamin D is found in oily fish, egg yolks, fortified cereals and some margarine spreads.

Most people need around 10 micrograms per day, which can also be obtained from supplements.

Vitamin D supports the mineral density of bones and aids neuromuscular function as well as reducing the risk of fracture.

The study was published in The Journals of Gerontology: Series A (Houston et al., 2012).

A high omega-3 diet can lower the signs and symptoms of the disease by 50 per cent.

Stiffness in the joints and swelling can be indirect signs of omega-3 deficiency, research suggests.

Waking up stiff in the morning, feeling pain in the joints, swelling, tenderness and loss of flexibility are all signs of arthritis.

Omega-3 deficiency could be contributing, as scientists believe there is a link between this leading cause of disability and a lack of omega-3 in the diet.

Researchers suggest that a diet rich in omega-3 could decrease the symptoms of osteoarthritis.

A study has found that adding fish oil to the diet — and to some degree flaxseed oil (alpha-linolenic acid has an anti-inflammatory effect) — can ease or even prevent osteoarthritis.

With population aging, osteoarthritis will be one of the leading causes of disability.

According to the Centers for Disease Control and Prevention, by 2040 it is estimated that 26% of US adults aged 18 or older will be diagnosed by a doctor with arthritis.

While there are still no effective medications for treating this condition, omega-3 fish oil can be one of the best natural remedies in treating osteoarthritis.

Professor John Tarlton, the lead researcher of the study, explained the effect of omega-3 on osteoarthritis:

“Classic early signs of the condition, such as the degradation of collagen in cartilage and the loss of molecules that give it shock-absorbing properties, were both reduced with omega-3.

Furthermore, there was strong evidence that omega-3 influences the biochemistry of the disease, and therefore not only helps prevent disease, but also slows its progression, potentially controlling established osteoarthritis.”

Western diets contain high levels of omega-6 fatty acids, which can lead to inflammatory disorders such as colitis, heart disease, osteoporosis, cancer, rheumatoid arthritis and osteoarthritis.

Modern diets contain up to 30 times more omega-6 than omega-3, whereas our ancestor’s diets contained almost an equal level of these two omega fatty acids.

Therefore, supplementation with omega-3 can help to restore this imbalance in Western diets and improve conditions such as colitis and heart-related diseases.

Fish oil is much more effective than flax seed oil, but for vegetarians and vegans this supplement is an important option.

Professor Tarlton concluded:

“Most diets in the developed world are lacking in omega-3, with modern diets having up to 30 times too much omega-6 and too little omega-3.

Taking omega-3 will help redress this imbalance and may positively contribute to a range of other health problems such as heart disease and colitis.”

The study was published in the journal of Osteoarthritis and Cartilage (Knott et al., 2011).

A daily supplement that reduces illness duration and makes the symptoms less severe.

A multi-vitamin with mineral supplements can improve immune function, making illnesses less severe and easing symptoms, especially in those who are 55 or older.

Taking a daily multi-vitamin and minerals supplement high in vitamin C for three months will lower the odds of catching a cold, respiratory infection, and pneumonia and also will reduce the length of illness and symptoms.

Micronutrients such as Vitamin C, vitamin D, and zinc are particularly essential for the immune system to function properly.

Scientist at OSU’s Linus Pauling Institute enrolled a group of healthy adults aged 55 and older to assess the effects of vitamin and mineral supplements on immune function.

For 12 weeks, the multi-vitamin and mineral supplement (MVM) group received a daily formulated MVM supplement (Redoxon® VI, Singapore) while the other group was on placebo supplementation.

The group who were on the MVM Redoxon supplement exhibited improved immune function and nearly a 70 percent reduction in the number of days sick.

In other words, the length of illness on average reduced from more than six days in the placebo group to less than three days in the MVM Redoxon group.

Moreover, the severity of illness among those in the placebo group was four times higher than those on the MVM supplement.

Professor Adrian Gombart, study co-author, said:

“The observed illness differences were striking.

While the study was limited to self-reported illness data and we did not design the study to answer this question, the observed differences suggest that additional larger studies designed for these outcomes are warranted — and, frankly, overdue.”

MVM Redoxon contains 700 mcg vitamin A, 45 mg vitamin E, 6.6 mg vitamin B6, 400 mcg folate, 9.6 mcg vitamin B12, 1,000 mg vitamin C, 400 IU vitamin D, 5 mg iron, 110 mg selenium, 0.9 mg copper, and 10 mg zinc.

Professor Gombart said:

“Supplementation was associated with significantly increased circulating levels of zinc and vitamin C, and with illness symptoms that were less severe and shorter lasting.

This supports findings that stretch back decades, even to the days of Linus Pauling’s work with vitamin C.

Our results suggest more and better designed research studies are needed to explore the positive role multivitamin and mineral supplementation might play in bolstering the immune system of older adults.”

Vitamin and mineral deficiency is more common as we get older and so this will lead to age-related immune system dysfunction.

Over one-third of older adults in Europe, the United States, and Canada are lacking one or more micronutrient.

Professor Gombart said:

“That likely contributes to a decline in the immune system, most often characterized by increased levels of inflammation, reduced innate immune function and reduced T-cell function.

Since multiple nutrients support immune function, older adults often benefit from multivitamin and mineral supplements.

These are readily available, inexpensive and generally regarded as safe.”

The study was published in the journal of Nutrients (Fantacone et al., 2020).

Anxiety, depression, aggressiveness and breaking rules can be signs of these mineral and vitamin deficiencies in boys.

Mental signs of a vitamin B12 deficiency include depression, memory issues, confusion and irritability.

Now, a study finds that children with behavioural problems might be deficient in important nutrients such as iron and B12.

A study has found that boys with low blood levels of vitamin B12 and iron could exhibit some problematic behaviours such as depression, anxiety, breaking rules, and being aggressive.

Professor Eduardo Villamor, the study’s co-author, said:

“Iron deficiency is still highly prevalent in many regions worldwide.

There is less data on vitamin B12 deficiency but available evidence also suggests it may be a substantial public health problem in certain populations.”

For this study, 3,202 children aged 5 to 12 years old from primary public schools were randomly selected and followed-up for 6 years.

The research team wanted to see if micronutrient deficiency in children would lead to mental health problems.

Several health issues were linked to poor diets lacking micronutrients such as iron and vitamin B12.

They found that internalizing and externalizing behaviours in male adolescents were strongly related to anaemia (iron deficiency), and low levels of vitamin B12 through their childhood.

Professor Villamor said:

“Interventions to curb these deficiencies must be informed by knowledge of their causes in each specific setting.

In our study population, for example, we showed before that a school snack program increased vitamin B12 blood levels after three months.”

Past studies have found that iron deficiency in infants would reduce the alertness, self-soothing, and self-regulation such as ability to focus, control body function, and manage emotions.

These issues possibly develop further during childhood and could lead to behavioural problems in teenagers and poor mental health in their adulthood.

The study didn’t find any link between vitamin B12 and iron deficiency among girls and behaviour problems.

This may be related to differences in physical and psychological changes at puberty between girls and boys.

Professor Villamor said:

“We don’t have a clear explanation of why there were sex differences, although we knew it was important to study boys and girls separately because they may differ in the timing of development.

Studies in rats have found that some micronutrient deficiencies affect male and female brains differently but it is not clear exactly why this may also be the case in humans.”

Physical rather than mental symptoms of a vitamin B12 deficiency include headaches, fatigue, breathlessness and pale skin.

Taking a B12 supplement is one of the easiest ways to combat this problem.

Adults need around 1.5 mcg per day.

The study was published in The Journal of Nutrition (Robinson et al., 2018).