Two Servings of Specific Vegetables Can Reduce Brain Age By 11 Years (M)
Just two daily servings containing vital nutrients is enough to reduce brain age by 11 years.
Category: Dementia
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Experimental Drug Reverses Alzheimer’s Disease In Mice (M)
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An Exercise Hormone Protects Against Alzheimer’s Disease
The hormone boosts neuronal growth in the hippocampus.
The hormone boosts neuronal growth in the hippocampus.
Physical exercise produces a hormone called irisin that may help protect against Alzheimer’s disease, research finds.
The hormone boosts neuronal growth in the hippocampus, a region of the brain critical for learning and memory.
Mice in the study who swam every day had no memory problems, despite being injected with a protein linked to Alzheimer’s.
Dr Ottavio Arancio, who led the study, said:
“This raised the possibility that irisin may help explain why physical activity improves memory and seems to play a protective role in brain disorders such as Alzheimer’s disease.”
Tests on mice revealed that the hormone irisin does indeed protect the brain’s synapses from damage and improve their memory.
Increasing levels of irisin was linked to better brain health in the mice.
In another study, mice were infused with beta amyloid, a protein linked to Alzheimer’s.
The results showed that those who swam every day for five weeks were free of memory problems.
When the researchers blocked irisin’s effect with drugs, the mice’s memory worsened.
This strongly suggests that irisin helps protect against Alzheimer’s.
Other research has shown that people with Alzheimer’s typically have low levels of irisin in their hippocampus.
The search is now on for drugs that can mimic its effect or increase levels of the hormone in the brain.
Dr Arancio said:
“In the meantime, I would certainly encourage everyone to exercise, to promote brain function and overall health.
But that’s not possible for many people, especially those with age-related conditions like heart disease, arthritis, or dementia.
For those individuals, there’s a particular need for drugs that can mimic the effects of irisin and protect synapses and prevent cognitive decline.”
The study was published in the journal Nature Medicine (Lourenco et al., 2019).
These Emotions Increase Alzheimer’s Risk
People with these conditions experience Alzheimer’s symptoms up to 7 years earlier.
People with these conditions experience Alzheimer’s symptoms up to 7 years earlier.
Both depression and anxiety increase the risk of developing Alzheimer’s disease.
People who are depressed develop the symptoms of Alzheimer’s, the most common form of dementia, two years earlier, the latest research finds.
Those with anxiety develop symptoms of Alzheimer’s three years earlier.
Having multiple mental health problems is linked to developing symptoms of the disease even sooner.
Dr Zachary A. Miller, the study’s first author, said:
“More research is needed to understand the impact of psychiatric disorders such as depression and anxiety on the development of Alzheimer’s disease and whether treatment and management of depression and anxiety could help prevent or delay the onset of dementia for people who are susceptible to it.
Certainly this isn’t to say that people with depression and anxiety will necessarily develop Alzheimer’s disease, but people with these conditions might consider discussing ways to promote long-term brain health with their health care providers.”
The study included 1,500 people with Alzheimer’s disease who were asked about their mental health.
The results revealed that the more mental health problems people had, the sooner they began experiencing dementia symptoms.
Three or more psychiatric disorders together was linked to developing symptoms more than 7 years earlier them.
Both depression and anxiety were linked to a history of autoimmune disorders.
Dr Miller said:
“While this association between depression and autoimmune disease, and seizures and anxiety is quite preliminary, we hypothesize that the presentation of depression in some people could possibly reflect a greater burden of neuroinflammation.
The presence of anxiety might indicate a greater degree of neuronal hyperexcitability, where the networks in the brain are overstimulated, potentially opening up new therapeutic targets for dementia prevention.”
The study will be presented at the American Academy of Neurology’s 73rd Annual Meeting (Miller et al., 2021).
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The Sleep Disorder Linked To Alzheimer’s (M)
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