This Cheap Supplement Slows Cognitive Decline (M)
A simple, inexpensive way to slow age-related cognitive decline.
A simple, inexpensive way to slow age-related cognitive decline.
Brain health can be improved, concludes a study of ‘super-agers’.
Brain health can be improved, concludes a study of ‘super-agers’.
The keys to ‘super-aging’ are embracing aging, quitting negativity, moving more and meditating, research on brain health suggests.
Super-agers are people in their 70s or 80s who have the mental and physical capabilities of someone decades younger.
In recent years, scientists have begun studying what separates super-agers from the rest.
Dr Joel Kramer, a neuropsychologist has been studying super-agers.
One particular super-ager inspired Dr Kramer:
“He talked about how his attitude toward life is one of embracing it—not getting stressed out by the little things and valuing the importance of relationships.
I was so impressed.
It was inspiring.”
The first key is to embrace the aging process because emotions tend to be more balanced with age.
Dr Elissa Epel, co-director of the UCSF Aging, Metabolism, and Emotions Center, explains:
“When we’re older, we seek positive situations in our life much more and cut out things we don’t like.
We take more control of our environment.
It’s because of the brains of elders.
We are more pro-social.
We are more likely to give to people in need than younger people.
This is not a huge surprise … but we’re now able to think of the biology of this.
We really need our elders.”
Fear of aging can be dangerous in itself — research suggests it is a self-fulfilling prophecy.
Dr Epel said:
“We hold these tremendously negative stereotypes about aging, and these start from when we’re really young.
By the time we’re older, these are actually having a negative effect on our health.”
Negative attitudes about aging can accelerate aging, so better to banish them.
Study after study shows the benefit of exercise.
It produces more new brain cells, improves well-being and physical health.
Exercise may even help protect against Alzheimer’s and other neurological diseases.
Meditation has been shown to reduce anxiety, depression and to have physiological benefits.
The research on super agers is from a range of scientists working at UCSF and elsewhere.
Type 2 diabetes doubles the risk of cognitive problems and dementia.
Type 2 diabetes doubles the risk of cognitive problems and dementia.
Many studies have shown that type 2 diabetes is linked to brain shrinkage and dementia.
Now a study finds that controlling blood sugar levels is the best way for people with type 2 diabetes to improve their brain function.
People who used diet and exercise to reduce blood sugar were able to think more clearly and to remember and learn more.
Losing weight, though, was not directly linked to better brain function.
This may be because the brain cannot recover from too much weight gain, said Professor Owen Carmichael, the study’s first author:
“It’s important to properly control your blood sugar to avoid the bad brain effects of your diabetes.
Don’t think you can simply let yourself get all the way to the obese range, lose some of the weight, and everything in the brain is fine.
The brain might have already turned a corner that it can’t turn back from.”
The study included almost 1,100 people who were tracked for over a decade.
One group were asked to focus on improving their blood sugar levels through diet and physical activity.
The other group did something similar but were focused on losing weight and maintaining that weight loss.
The results demonstrated the benefits to the brain of exercising and eating healthily.
However, weight loss did not provide a consistent improvement to brain function.
Weight loss was linked to improvements in cognitive skills like attention, memory and planning but verbal learning and overall memory got worse.
Professor Carmichael said:
“Every little improvement in blood sugar control was associated with a little better cognition.
Lowering your blood sugar from the diabetes range to prediabetes helped as much as dropping from prediabetes levels to the healthy range.”
Over 25 percent of US adults over 65 have type 2 diabetes.
It doubles the risk of cognitive problems and dementia.
Avoiding obesity is one key to fighting the disease.
Professor Carmichael said:
“The results were worse for people who had obesity at the beginning of the study.
That’s a ‘too little, too late’ type of message.
People with diabetes who let their obesity go too far, for too long may be past the point of no return, cognition-wise.”
The study was published in The Journal of Clinical Endocrinology & Metabolism (Carmichael et al., 2020).
One-quarter of the population has fatty liver disease, along with 80 percent of those who are morbidly obese.
With age, blood flow to the brain and arterial function decreases — but this decline can be slowed.
With age, blood flow to the brain and arterial function decreases — but this decline can be slowed.
High-intensity interval training is the best exercise for preventing cognitive decline, research suggests.
Interval training is more effective than continuous training for increasing blood flow to the brain, scientists found.
Interval training (HIIT) involves short bursts of maximum effort, followed by periods of rest.
Interval training comes in a variety of guises: sometimes on a bicycle, other times running, jogging or speed walking
Typically, it involves exercising at maximum intensity for 30 seconds and then taking four minutes to recover.
This cycle is then repeated a few times.
Dr Tom Bailey, study co-author, said:
“As we age, the flow of blood to the brain and arterial function decreases.
These factors have been linked to a risk of cognitive decline and cardiovascular events, such as stroke.
Finding ways to increase brain blood flow and function in older adults is vital.”
The study included 21 people who either did interval cycling or who cycled continuously for around 10 minutes.
The results showed that blood flow in the brain was greater during interval training.
Dr Tom Bailey, study co-author, said:
“One of the key takeaways from the study was that both the exercise and the rest period were important for increasing brain blood flow in older adults.
This study shows that interval-based exercise was as effective as continuous exercise for increasing brain blood flow in older adults during the periods of activity, and more effective than continuous exercise when we measured the overall blood flow increases during both the exercise and the rest periods.
The benefits of exercise on brain function are thought to be caused by the increase in blood flow and shear stress, the frictional force of blood along the lining of the arteries, which occurs during exercise.
This study aimed to identify the type or format of exercise that causes the greatest increases in brain blood flow, so we could help to optimize exercise programs to enhance brain function.”
The study was published in the journal Medicine & Science in Sports & Exercise (Klein et al., 2019).
Prediabetes can be reversed by eating a healthy, well-balanced diet, being active and by maintaining a healthy weight.
Prediabetes can be reversed by eating a healthy, well-balanced diet, being active and by maintaining a healthy weight.
People with high blood sugar levels are at markedly increased risk of dementia and poor brain health, research finds.
Having higher blood sugar levels than normal is known as prediabetes and puts people at higher risk of developing diabetes.
Symptoms of high blood sugar can include:
However, sometimes people with elevated blood sugar levels get no symptoms.
Prediabetes can be reversed by eating a healthy, well-balanced diet, being active and by maintaining a healthy weight.
The study included over half-a-million people who were tracked over around four years.
Researchers found that people with elevated blood sugar levels were at a 54 percent higher risk of vascular dementia and a 42 percent higher risk of cognitive decline.
The increases in risk for cognitive decline was similar to those seen for full-blown diabetes, suggesting that high blood sugar is damaging the brain.
Brain scans revealed that high blood sugar was linked to a smaller hippocampus, a brain structure important for memory.
Elevated blood sugar was also linked to more damage to the brain’s white matter, which is important for information flow around the brain.
Dr Victoria Garfield, the study’s first author, said:
“Our research shows a possible link between higher blood sugar levels — a state often described as ‘prediabetes’ — and higher risks of cognitive decline and vascular dementia.
As an observational study, it cannot prove higher blood sugar levels cause worsening brain health.
However, we believe there is a potential connection that needs to be investigated further.
Previous research has found a link between poorer cognitive outcomes and diabetes but our study is the first to investigate how having blood sugar levels that are relatively high — but do not yet constitute diabetes — may affect our brain health.”
The people in the study’s average age was 58, which is relatively low for dementia and cognitive decline, explained Professor Nishi Chaturvedi, study co-author:
“In this relatively young age group, the risks of cognitive decline and of dementia are very low; the excess risks we observe in relation to elevated blood sugar only modestly increase the absolute rates of ill health.
Seeing whether these effects persist as people get older, and where absolute rates of disease get higher, will be important.”
The study was published in the journal Diabetes, Obesity and Metabolism (Garfield et al., 2021).
Higher brain aging leads to shrinking of the white and gray matter and worse scores on standard cognitive tests.
Communication between areas of the brain starts to break down when people approach their 50s.
Communication between areas of the brain starts to break down when people approach their 50s.
A ketogenic diet — one low in simple carbohydrates — may help to reverse brain aging, research finds.
Reducing the consumption of simple carbs can prevent or reverse age-related changes to the brain.
Simple carbs are contained in foods like soda, baked goods, cookies and some breakfast cereals.
Complex carbs are found in foods like vegetables, fruits, beans, nuts and whole grains.
Even in people below the age of 50, in whom brain aging has not yet taken hold, switching to a low-carb or ketogenic diet increases brain activity, the researchers found.
Professor Lilianne R. Mujica-Parodi, the study’s first author, said:
“What we found with these experiments involves both bad and good news.
The bad news is that we see the first signs of brain aging much earlier than was previously thought.
However, the good news is that we may be able to prevent or reverse these effects with diet, mitigating the impact of encroaching hypometabolism by exchanging glucose for ketones as fuel for neurons.”
The scientists examined almost 1,000 brain scans of people aged 18 to 88.
The results showed that communication between areas of the brain starts to break down when people approach their 50s.
The most rapid deterioration of the brain happened around 60-years-old.
This destabilisation was linked to worse cognition and accelerating insulin resistance.
However, further experiments showed that changing to a ketogenic diet can retard or even reverse the process of brain aging.
Professor Mujica-Parodi said:
“We think that, as people get older, their brains start to lose the ability to metabolize glucose efficiently, causing neurons to slowly starve, and brain networks to destabilize.
Thus, we tested whether giving the brain a more efficient fuel source, in the form of ketones, either by following a low-carb diet or drinking ketone supplements, could provide the brain with greater energy.
Even in younger individuals, this added energy further stabilized brain networks.”
A low-carb, or ketogenic diet works by providing more energy to cells in the form of ketones than glucose.
Ketones provide more energy, said Professor Mujica-Parodi:
“This effect matters because brain aging, and especially dementia, are associated with “hypometabolism,” in which neurons gradually lose the ability to effectively use glucose as fuel.
Therefore, if we can increase the amount of energy available to the brain by using a different fuel, the hope is that we can restore the brain to more youthful functioning.”
The study was published in the journal PNAS (Mujica-Parodi et al., 2020).
The diet lowers the risk of developing dementia later in life.
People’s brain health and its physical size naturally decline with age.
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