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The First Safe COVID-19 Vaccine Passes Phase 1 Trial

The First Safe COVID-19 Vaccine Passes Phase 1 Trial post image

The first COVID-19 vaccine is safe for phase 2 human test and could be ready in six months.

The first vaccine against SARS-CoV-2 has completed the phase 1 clinical trial showing promising results and is moving on to phase 2.

The new COVID-19 vaccine was injected in 108 healthy adults and was found to be well-tolerated, safe, and produced a good immune response against the virus.

A phase 2 trial has been started to see if the results can be replicated in a larger population with no harmful effect after vaccination for 6 months.

Professor Wei Chen, study senior author, said:

“These results represent an important milestone.

The trial demonstrates that a single dose of the new adenovirus type 5 vectored COVID-19 (Ad5-nCoV) vaccine produces virus-specific antibodies and T cells in 14 days, making it a potential candidate for further investigation.

However, these results should be interpreted cautiously.

The challenges in the development of a COVD-19 vaccine are unprecedented, and the ability to trigger these immune responses does not necessarily indicate that the vaccine will protect humans from COVID-19.

This result shows a promising vision for the development of COVID-19 vaccines, but we are still a long way from this vaccine being available to all.”

Right now everybody thinks that vaccination is the best solution against the COVID-19 pandemic.

This has countries competing to be first in discovering the vaccine.

As a result, over 100 candidate COVID-19 vaccines are in development.

The Ad5-nCoV vaccine is one of the candidates and also the first one that has been tested in a human trial.

The vaccine contains a weak common cold virus known as adenovirus which causes a respiratory infection.

It provides the genetic material of the SARS-CoV-2 spike protein causing the immune system to produce antibodies that can identify spike proteins and so defeat the COVID-19 virus.

The Ad5-nCoV vaccine was administered to healthy adults in various doses with no SARS-CoV-2 infection.

All doses were tolerated and side-effects included fever, headache, muscle pain, fatigue, and mild pain caused by the injection which lasted for less than 2 days.

Twenty-eight days after vaccination, antibodies binding to the antigen increased by a four times in most subjects.

They either had SARS-CoV-2-neutralizing antibodies or a positive T cell response against the virus.

Professor Feng-Cai Zhu, the study’s first author, said:

“Our study found that pre-existing Ad5 immunity could slow down the rapid immune responses to SARS-CoV-2 and also lower the peaking level of the responses.

Moreover, high pre-existing Ad5 immunity may also have a negative impact on the persistence of the vaccine-elicited immune responses.”

The phase 2 trial of the Ad5-nCoV vaccine has already started to find out if the results can be reproduced in a larger population and among people over 60.

They also want to see if there are any serious side-effects six months after vaccination.

About the author

Mina Dean is a Nutritionist and Food Scientist. She holds a BSc in Human Nutrition and an MSc in Food Science.


The study was published in The Lancet (Zhu et al., 2020).